Unfortunately not, below is the entire code. If I comment out

AddHandler dropDownItem.Click, AddressOf OptionClick

It will run and the com ports are there but obviously nothing happens when I select them.

I have been using a regular combo box for now, but it would be nice to have everything nice and neat in a settings instead of in the form all the time.

Imports System
Imports System.ComponentModel
Imports System.Threading
Imports System.IO.Ports

Public Class Form1
Dim myPort As Array 
Private Sub frmMain_Load(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles MyBase.Load
    myPort = IO.Ports.SerialPort.GetPortNames() 

    For Each port In myPort

        Dim dropDownItem As ToolStripItem = commportlist.DropDownItems.Add(port)
        AddHandler dropDownItem.Click, AddressOf OptionClick

    Next

End Sub


Private Sub OptionClick(ByVal sender As Object, ByVal e As EventArgs)

    Dim itemClicked As ToolStripMenuItem
    itemClicked = CType(sender, ToolStripMenuItem)
    MsgBox("You have selected the item " & itemClicked.Text)

End Sub

End Class